Journal article
The impact of statins on psychological wellbeing: 12A systematic review and meta-analysis
A O'Neil, L Sanna, C Redlich, K Sanderson, F Jacka, LJ Williams, JA Pasco, M Berk
BMC Medicine | BMC | Published : 2012
Abstract
Background: Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and improving mood. However, evidence regarding their effects remains inconsistent, with some studies reporting links to mood disturbances. We aimed to conduct a meta-analysis to determine the impact of statins on psychological wellbeing of individuals with or without hypercholesterolemia.Methods: Articles were identified using medical, health, psychiatric and social science databases, evaluated for quality, and data were synthesized and analyzed in RevMan-5 software using a random effects model.Results: The 7 randomized controlled tr..
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Awarded by Seventh Framework Programme
Funding Acknowledgements
FJ has received grant/research support from the Brain and Behaviour Research Institute, the National Health and Medical Research Council, Australian Rotary Health, the Geelong Medical Research Foundation, the Ian Potter Foundation, Eli Lilly and The University of Melbourne and has been a paid speaker for Sanofi-Synthelabo, Janssen Cilag and Eli Lilly. MB has received grant/research support from the NIH, Simons Foundation, CRC for Mental Health, Stanley Medical Research Institute, MBF, NHMRC, Beyond Blue, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Organon, Novartis, Mayne Pharma, Servier and Astra Zeneca. He has been a paid consultant for Astra Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck and Pfizer and a paid speaker for Astra Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck, Organon, Pfizer, Sanofi Synthelabo, Solvay and Wyeth. LJW has received grant/research support from Eli Lilly, Pfizer, The University of Melbourne, Deakin University and the National Health and Medical Research Council. JAP has received speaker fees from Amgen, Eli Lilly and Sanofi-Aventis and funding from the Geelong Region Medical Research Foundation, Barwon Health, Perpetual Trustees, the Dairy Research and Development Corporation, The University of Melbourne, the Ronald Geoffrey Arnott Foundation, ANZ Charitable Trust, the American Society for Bone and Mineral Research, Amgen (Europe) GmBH and the NHMRC. AO'N, KS, FJ and LJW are supported by a National Health and Medical Research Council (NHMRC) project grant (#1021347), an Australian Research Council Future Fellowship (FT991524), a NHMRC Post-doctoral Training Fellowship (#628912), and an Alfred Deakin Postdoctoral Research Fellowship, respectively.